Investors have had just their second November session of losses on the Australian market after momentum created by hope of a coronavirus vaccine eased.

The S&P/ASX200 benchmark index closed lower by 31.5 points, or 0.49 per cent, to 6418.2 on Thursday.

The All Ordinaries closed down 31.7 points, or 0.48 per cent, to 6619.4.

Financials, materials and energy lost about one per cent or more.

The ASX result follows two sessions of widespread enthusiasm by investors after Pfizer’s announcement that its coronavirus vaccine, being developed, was 90 per cent effective.

The Aussie dollar was buying 72.73 US cents at 1621 AEDT, lower from 73.09 US cents at Wednesday’s close.